Nuno founded the gallery and has established an international program of Contemporary Art. Galeria Nuno Centeno begun as Reflexus Contemporary Art, situated in a town house with three spaces opening on March 2007 in Porto. Quickly gain visibility and reputation by discovering a new scene in town. Alongside with Serralves Museum and the artist-run A Certain Lack of Coherence the gallery has played an important role in showcasing Contemporary Art in Porto. In 2009 the gallery expanded, moving to larger premises. The name changed to Galeria Nuno Centeno in January 2011 and started to represent a group of emerging and established international artists that made the gallery reputation. Nuno is son of well known Portuguese artist Sobral Centeno.
In 2016 with less than 10 years of career Nuno Centeno was nominated by Artnet as the "Europe's 10 Most Respected Art Dealers". In 2018 won Frieze New York Focus Prize and judges described the presentation as "bold" and "showcasing the work of artists with an interesting dialogue", resulting in a "poised freshness".
In September 2018, Apollo International Art Magazine published Apollo 40 Under 40 Europe, a magazine dedicated to 40 of the most influential and talented people in the art world who are based in Europe and under the age of 40.
Nuno Centeno has been participating in major art fairs and events such as Frieze London & New York / Independent Brussels & New York / Miami Art Basel / ARCO Madrid & Lisboa / Artissima / Art Brussels / Zona Maco Mexico / Liste Basel / CONDO London and CONDO São Paulo / Friend Of A Friend Warsaw
The gallery aims to contribute for an healthy ecosystem, where the artist, dealer and collector runs in the same direction. Nuno Centeno also took part of the art fair selection committee for ARCO Lisboa and integrates the Oporto city advisory board for the cultural and art department. Alongside with the gallery, Nuno is founder/director of the Artist Book Gallery (an art gallery specializing in single edition artists's books) and Co-founder of The Spot (an outdoor project).